Targeted Libraries

The libraries contain in-stock compounds with pSEA1 value greater than 50. All libraries are available as a full or a cherry-picked set. We supply the compounds as solids, DMSO solutions, or dry films in vials or 96, 384 well plates.
List of proteins (sorted by the human gene names):

ACE Angiotensin-converting enzyme sdf
ACE2 Angiotensin-converting enzyme 2 sdf
ACKR3 Atypical chemokine receptor 3 sdf
ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 (ADAM 9) sdf
AGTR2 Angiotensin II type-2 receptor sdf
AKR1C3 Aldo-keto reductase family 1 member C3 sdf
BRCA1 Breast cancer type 1 susceptibility protein sdf
CAPN1 Calcium-activated neutral proteinase 1 sdf
CASP3 Caspase-3 sdf
CASP7 Caspase-7 sdf
CCR2 C-C chemokine receptor type 2 (C-C CKR-2) sdf
CCR3 C-C chemokine receptor type 3 (C-C CKR-3) sdf
CCR5 C-C chemokine receptor type 5 (C-C CKR-5) sdf
CCR8 C-C chemokine receptor type 8 (C-C CKR-8) sdf
CFTR Cystic fibrosis transmembrane conductance regulator sdf
CHRNA10 Neuronal acetylcholine receptor subunit alpha-10 sdf
CPA1 Carboxypeptidase A1 sdf
CPT1A Carnitine palmitoyltransferase 1A sdf
CPT2 Carnitine palmitoyltransferase I sdf
CTSA Cathepsin A sdf
DPP7 Dipeptidyl peptidase 7 sdf
ECE1 Endothelin-converting enzyme 1 sdf
ELANE Elastase-2 sdf
ETHR Thyroid hormone receptor beta sdf
FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A sdf
FPR1 N-formyl peptide receptor sdf
HCN1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 sdf
HTR1A 5-hydroxytryptamine receptor 1A sdf
INHA Inhibin alpha chain sdf
ITGA4 Integrin alpha-4 sdf
KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 sdf
LGMN Legumain sdf
LIPG Endothelial lipase sdf
MBTPS1 Membrane-bound transcription factor site-1 protease sdf
MLNR Motilin receptor G-protein coupled receptor 38) sdf
MME Neprilysin sdf
NOS2 Nanos homolog 2 (NOS-2) sdf
OPRD1 Delta-type opioid receptor (D-OR-1) (DOR-1) sdf
P2RX7 P2X purinoceptor 7 (P2X7) sdf
PREP Prolyl endopeptidase sdf
RBP4 Retinol-binding protein 4 sdf
SFRP1 Secreted frizzled-related protein 1 sdf
SIGMAR1 Sigma non-opioid intracellular receptor 1 sdf
SLC6A1 Sodium- and chloride-dependent GABA transporter 1 sdf
ST14 Suppressor of tumorigenicity 14 protein sdf
TIMP3 Tissue inhibitor of metalloproteinases 3 sdf
TMPRSS11D Transmembrane protease serine 11D sdf
TRPC6 Short transient receptor potential channel 6 sdf
WNT3 Proto-oncogene Wnt-3 sdf
XIAP E3 ubiquitin-protein ligase XIAP sdf
  1. Keiser MJ, Roth BL, Armbruster BN, Ernsberger P, Irwin JJ, Shoichet BK. Relating protein pharmacology by ligand chemistry. Nat Biotech 25 (2), 197-206 (2007)

The following focused and targeted libraries are available upon request:

Anti-cancer covalent kinase-oriented set
Anti-cancer kinase library
Appoptotic library
Aquaporins targeted library
Caspase focused library
Frequent hitters library (PAINS)
Ion channel modulators
Matrix metalloproteinases targeted library
PDE10 + PDE5/3 targeted library
PPI targeted library
Protease inhibitors library
REDOX library
Signaling pathways targeted library